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BIOTAGE biotage isolera
Biotage Isolera, supplied by BIOTAGE, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/biotage+isolera/biotage+isolera+one/us12365655-1287-58-60
Average 90 stars, based on 1 article reviews
biotage isolera - by Bioz Stars, 2026-09
90/100 stars

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Article Title: Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy.
Article Snippet: The mixture was then concentrated, and the residue was adsorbed on Isolute and purified via flash chromatography (Biotage Isolera, 50 g of SNAPUltra silica gel, cyclohexane/ethyl acetate/methanol gradient).

Article Title: Compounds
Article Snippet: A solution of 4-chloro-5-methylbenzo[d]isoxazol-3-amine A4 (100 mg, 0.548 mmol) and 2-methoxy-5-ethylsulfonyl chloride I112 (129 mg, 0.548 mmol) in pyridine (2 mL) was irradiated in the microwave for 2 hours at 100° C. Upon cooling, the reaction mixture was added to water, the precipitate was removed by filtration and the filtrate was loaded onto silica gel and purified by column chromatography (Biotage Isolera, 24 g SiO2 cartridge, 0-100% EtOAc in petroleum benzine 40-60° C.) to give the title compound as a white solid (33 mg, 16%).

Article Title: Factor XIIA inhibitors
Article Snippet: The crude material was partially-purified by column chromatography (Biotage Isolera, SNAP KP-Sil 340 g, dry loaded on celite, gradient i-hexane/EtOAc from 99:1 to 90:10) to give a sample of (R)-4-trifluoromethane sulfonyloxy-2,5-dihydro-pyrrole-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester (8.22 g, 30%) as a yellow oil, which was used ‘as is’ in subsequent reactions.

Article Title: Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy.
Article Snippet: The residue was adsorbed on isolute and purified via flash chromatography (Biotage Isolera, 100 g of SNAPUltra silica gel, cyclohexane−ethyl acetate gradient).

Article Title: Compounds
Article Snippet: A solution of 7-fluorobenzo[d]isoxazol-3-amine A3 (100 mg, 0.657 mmol) and 2-methoxy-5-ethylsulfonyl chloride I112 (154 mg, 0.657 mmol) in pyridine (2 mL) was irradiated in the microwave for 2 hours at 100° C. Upon cooling, the reaction mixture was loaded onto silica gel and purified by column chromatography (Biotage Isolera, 24 g SiO2 cartridge, 0-100% EtOAc in petroleum benzine 40-60° C.) to yield the title compound as a white solid (127 mg, 55%).

Article Title: Discovery of BAY 3389934 Hydrochloride: A Potent and Selective Small-Molecule Dual Factor IIa/Xa Inhibitor with Short Half-Life for the Acute Treatment of Sepsis-Induced Coagulopathy.
Article Snippet: The residue was purified in two portions via flash chromatography (Biotage Isolera, 100 g SNAP-Ultra silica gel, cyclohexane−ethyl acetate gradient).

Column Chromatography:

Article Title: Conjugates comprising cleavable beta-glucuronide-containing linkers
Article Snippet: .. General Information Flash chromatography was performed using a BIOTAGE ISOLERA and fractions checked for purity using thin-layer chromatography (TLC). .. TLC was performed using MERCK KIESELGEL 60 F254 silica gel, with fluorescent indicator on aluminium plates.

Article Title: Approaching the Spin-Statistical Limit in Visible-to-UV Photon Upconversion
Article Snippet: 1,4-bis((triisopropylsilyl)ethynyl)naphthalene (TIPS-Naph) was synthesized according to a literature procedure (vide infra).1 THF used for the synthesis of TIPS-Naph was dried on an MBraun MB SPS-800 solvent purification system. .. Column chromatography was performed on a Biotage Isolera using pre-packed silica columns (50g Biotage® SNAP Cartridge). ..

Thin Layer Chromatography:

Article Title: Conjugates comprising cleavable beta-glucuronide-containing linkers
Article Snippet: .. General Information Flash chromatography was performed using a BIOTAGE ISOLERA and fractions checked for purity using thin-layer chromatography (TLC). .. TLC was performed using MERCK KIESELGEL 60 F254 silica gel, with fluorescent indicator on aluminium plates.



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